The Agent20XY series of workshop were jointly held from 1999-2007 at the University of Chicago, Argonne National Laboratory, and Northwestern University, and were intended to provide a meeting ground for a stimulating exchange of diverse views. Indeed, a topic reiterated throughout the workshops was the importance of continued conversation between experts concerned with the content, theories, and conclusions of individual subject domains and experts concerned with advancing the art and science of simulation. From such conversations there surely arose many unexpected and fruitful applications of the concepts and tools of complex adaptive systems. The proceedings are presented in that spirit.

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